Inflammatory response is caused by chemical mediators like histamine and bradykinin. Other chemicals include cytokines, complement proteins, leukotrienes and prostaglandins. Histamine, released by mast cells acts on the smooth muscle and increases vascular permeability. Bradykinin aids pain perception and is released as a response to infection or injury.
Cytokines act as messengers between different types of white blood cells (e.g., macrophages, lymphocytes) and other tissues—while complement proteins act as part of the body’s innate defense system by targeting invading pathogens or initiating clotting processes when necessary. All these chemicals play important roles during the inflammatory response by helping coordinate the body’s efforts towards fighting off infection or healing damaged tissue etc.