Alterations in the homeostatic state secondary to gender, genetic, ethnic and temporal variables can have a significant impact on an individual’s health. The gender can affect hormone production, and genetics could predispose people to diseases. Ethnicity may also influence how organisms respond to stressors in the environment, like diet and temperature. Finaly, time variables like age and seasonality can affect an organism’s ability to keep its internal environment in a narrow range. As such, it is important for healthcare providers to take into account all of these factors when evaluating and treating their patients’ health.