Another event that has influenced the development of ethical codes and regulations for nursing and healthcare research is known as “the Tuskegee syphilis study”. The Tuskegee syphilis study was started in 1932, when 600 African American men who had syphilis without consent were recruited to take part in an experiment that aimed to see how untreated disease would develop over time. These men were not told what they were being tested for and continued to receive no treatment after the penicillin cure became available several years later. In response to this scandalous US experiment, several ethics guidelines were established in relation to informed consent and protection against harm when conducting research, as well as respecting autonomy in clinical trials.