To answer the question I created a searchable query based on all of the provided information. My initial question was “What is the appropriate diagnostic workup for a patient with fever, malaise, chest pain and shortness of breath?”. Then I developed a search strategy using keywords such as ‘diagnostic workup’, ‘fever’, ‘chest pain’ and ‘shortness of breath’ in order to find related articles from academic journals and other sources. I conducted a search and then read several articles that were relevant. Then, I synthesized the content of these articles into my response. To further refine my answer, I also read a couple of textbooks on possible differential diagnosis for these symptoms. In order to ensure the accuracy of my response, I cross-referenced information from different sources as often as possible.